17 February 2000
Dr. Pauline O'Grady
Dana Farber Cancer Institute, Harvard Medical School, Boston.
"The Extracellular Matrix Molecule Laminin as a Ligand for the LAR Receptor Tyrosine Phosphatase."
Contact: Tom Wileman

The expression of genes in cells is regulated by signal transduction pathways. Signal transduction pathways in turn are modulated by cycles of tyrosine phosphorylation and dephosphorylation, and these reactions are carried out by kinases and phosphatases. LAR (Leukocyte Antigen Related molecule) was discovered at the Dana Farber Cancer Institute in Boston and has become a model for a family of receptor tyrosine phosphatases expressed in many cell types. The LAR protein has an extracellular domain which binds laminin, a component of the extracellular matrix, and an intracellular domain with phosphatase activity.

This talk will cover the role of laminin and LAR signalling during modulation of cell adhesion, migration and cell survival.